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Last 5 years pubblications

Last 10 IPCB publications on ISI journals

1) Sequencing Biodegradable and Potentially Biobased Polyesteramide of Sebacic Acid and 3-Amino-1-propanol by MALDI TOF-TOF Tandem Mass Spectrometry
P.Rizzarelli, S.La Carta, E.F.Mirabella, M.Rapisarda, G.Impallomeni
Polymers  14(8),  1500  - 2022
Biodegradable and potentially biobased polyesteramide oligomers (PEA-Pro), obtained from melt condensation of sebacic acid and 3-amino-1-propanol, were characterized by nuclear magnetic resonance (NMR), matrix assisted laser desorption/ionization-time of flight/time of flight-mass spectrometry/mass spectrometry (MALDI-TOF/TOF-MS/MS), thermogravimetric analysis (TGA), and pyrolysis-gas chromatography/mass spectrometry (Py-GC/MS). NMR analysis showed the presence of hydroxyl and amino terminal groups as well as carboxylic groups of the sebacate moiety. Hydroxyl and carboxyl termination had the same abundance, while the amine termination was 2.7-times less frequent. Information regarding the fragmentation pathways and ester/amide bond sequences was obtained by MALDI-TOF/TOF-MS/MS analysis performed on sodiated adducts of cyclic species and linear oligomers. Different end groups did not influence the observed fragmentation. Three fragmentation pathways were recognized. The β-hydrogen-transfer rearrangement, which leads to the selective scission of the -O-CH2- bonds, was the main mechanism. Abundant product ions originating from -CH2-CH2- (β-γ) bond cleavage in the sebacate moiety and less abundant ions formed by -O-CO- cleavages were also detected. TGA showed a major weight loss (74%) at 381 °C and a second degradation step (22% weight loss) at 447 °C. Py-GC/MS performed in the temperature range of 350-400 °C displayed partial similarity between the degradation products and the main fragments detected in the MALDI-TOF/TOF-MS/MS experiments. Degradation products derived from amide bonds were related to the formation of CN groups, in agreement with the literature.

IPCB graphical abstract

2) Superparamagnetic Iron Oxide Nanoparticle Nanodevices Based on Fe3O4 Coated by Megluminic Ligands for the Adsorption of Metal Anions from Water
S.Scurti, S.Dattilo, D.Gintsburg, L.Vigliotti, A.Winkler, S.C.Carroccio, D.Caretti
ACS Omega   - 2022
The uptake ability toward arsenic(V), chromium(VI), and boron(III) ions of ad hoc functionalized magnetic nanostructured devices has been investigated. To this purpose, ligands based on meglumine have been synthesized and used to coat magnetite nanoparticles (Fe3O4) obtained by the co-precipitation methodology. The as-prepared hybrid material was characterized by infrared spectroscopy (IR), X-ray diffraction, thermogravimetric analysis, and scanning electron microscopy combined with energy-dispersive X-ray analysis. Moreover, its magnetic hysteresis properties were measured to evaluate its magnetic properties, and the adsorption kinetics and isothermal models were applied to discern between the different adsorption phenomena. Specifically, the better fitting was observed by the Langmuir isotherm model for all metal ions tested, highlighting a higher uptake in arsenic (28.2 mg/g), chromium (12.3 mg/g), and boron (23.7 mg/g) sorption values if compared with other magnetic nanostructured materials. After adsorption, an external magnetic stimulus can be used to efficiently remove nanomaterials from the water. Finally the nanomaterial can be reused up to five cycles and regenerated for another three cycles.

IPCB graphical abstract

3) Spontaneous polymerization of benzofulvene derivatives bearing complexed or un-complexed pyridine rings
M.Paolino, M.Saletti, A.Reale, V.Razzano, G.Giuliani, A.Donati, C.Bonechi, G.Giorgi, A.Atrei, M.Mauro, A.Scamporrino, F.Samperi, E.Fois, G.Tabacchi, C.Botta, A.Cappelli
European Polymer Journal  169,  111137  - 2022
Benzofulvene derivatives bearing complexed and un-complexed pyridine rings are designed and synthesized to assess the effects on the spontaneous solid-state polymerization of the presence in position 6 of the 3-phenylbenzofulvene moiety of bulky substituents capable of establishing metallophilic interactions. Both the benzofulvene monomers are found to polymerize spontaneously upon solvent removal under reduced pressure in the apparent absence of catalysts or initiators. The resulting polybenzofulvene derivatives are characterized by NMR spectroscopy, MALDI-TOF mass spectrometry, and in photophysical studies.

IPCB graphical abstract

4) Carbazole-Pyridazine copolymers and their rhenium complexes: Effect of the molecular structure on the electronic properties
S.Zappia, L.Veronese, A.Fornic, S.Dattilo, F.Samperi, J.Dagare, T.M.Brown, M.Panigati, S.Destri
European Polymer Journal  168,  111095  - 2022
Two new push-pull copolymers, poly[N-(9-heptadecanyl)carbazole-2,7-diyl-alt-phthalazine- 5,8-diyl] (P1) and poly[N-(9-heptadecanyl)carbazole-2,7-diyl-alt-thieno[3,4-d]pyridazine- 5,7-diyl] (P2), were synthetized by means of a Suzuki polycondensation. The molecular characterization with 1H NMR and MALDI-MS showed enchainment defects in the polymer backbones depending on the synthetic conditions (catalyst and temperature). Both carbazole-carbazole and diazine-diazine homocoupling defects occurred, particularly in the case of P2. For P1, instead, almost homocoupling-free material was obtained. Exploiting the metal coordination capability of the pyridazine ring, corresponding dinuclear rhenium-based metallopolymers, ReP1 and ReP2, were also synthetized. All materials were investigated with experimental techniques (UV-vis spectroscopy, photoluminescence, cyclic voltammetry) and corroborated by theoretical studies (DFT and TD-DFT), including a qualitative evaluation of the effects of backbone defects on the electronic properties of the polymers. They were also tested in organic photovoltaic (OPV) devices. The wide energy gaps (Eg) accompanied with a low absorption coefficient for the band in the visible range reduced the harvesting capability of the copolymers. These drawbacks were partially overcome in the metallopolymers. The low device performance was mainly attributable to the low solubility of the metallopolymers in the organic solvents.

IPCB graphical abstract

5) COG6-CDG: Novel variants and novel malformation
L.Cirnigliaro, P.Bianchi, L.Sturiale, D.Garozzo, G.Mangili, L.Keldermans, R.Rizzo, G.Matthijs, A.Fiumara, J.Jaeken, R.Barone
Birth Defects Research  114(5-6),  165-174  - 2022
Deficiency of Conserved Oligomeric Golgi (COG) subunits (COG1?8) is characterized by both N- and O-protein glycosylation defects associated with destabilization and mislocalization of Golgi glycosylation machinery components (COG-CDG). Patients with COG defects present with neurological and multisystem involvement and possible malformation occurrence. Eighteen patients with COG6-CDG (COG6 mutations) were reported to date. We describe a patient with COG6-CDG with novel variants and a novel clinical feature namely a congenital recto-vaginal fistula.
In-depth serum N- and O-glycosylation structural analyses were conducted by MALDI-TOF mass spectrometry. COG6 variants were identified by a gene panel and confirmed by Sanger sequencing.
This female newborn presented with facial dysmorphism, distal arthrogryposis and recurrent stool discharges per vaginam. A double-contrast barium-enema X-ray study revealed a dehiscence (approximately 5 mm) at the anterior wall of the rectal ampoule communicating with the vagina consistent with a recto-vaginal fistula. She had developmental delay, corpus callosum dysgenesis, liver and gastrointestinal involvement, hyperthermia episodes and early demise. Serum N- and O-glycosylation analyses pointed to a profound Golgi disarrangement. We identified two novel variants in COG6: a deletion of 1 bp mutation c.823delA creating a shift in the reading frame and a premature stop codon and a 3 bp deletion (c.1141_1143delCTC) producing an in-frame deletion of 1 amino acid.
The congenital recto-vaginal fistula is a rare type of anorectal malformation that, to our knowledge, has not been reported in patients with a COG6 defect nor in patients with other COG defects. This study broadens COG6-CDG genetic landscape and spectrum of malformations.

6) Characterization of VOCs and additives in Italian PET bottles and studies on potential functional aldehydes scavengers
S.Dattilo, C.Gugliuzzo, E.F.Mirabella, C.Puglisi, A.Scamporrino, D.Zampino, F.Samperi
European Food Research and Technology  248  - 2022
This study focused on characterization of Volatile Organic Compounds (VOCs) as contaminants and non-volatile additives in Italian PET bottles, also suggesting potential functional aldehydes scavengers. Several VOCs, such as acetic aldehyde (AA), butanal, 3-methyl butanal, 1,3-dioxolane, pentanal, hexanal, octanal, 5-hepten-2-one, nonanal, and decanal, were identified by Head Space-Gas Chromatography/Mass Spectrometry (HS-GC/MS) in the PET bottles used for the packaging of six Italian brands mineral waters. AA, 1,3-dioxolane, octanal, 5-hepten-2-one, nonanal, and decanal were the most abundant compounds identified. These contaminants were also identified in the PET-bottled mineral waters. Different experiments using bottle-grade PET pellets (Btlg-PET) and PET bottles’ fragments with and without the addition of epoxidized soybean oil (ESBO) or erucamide as lubricant/plasticizer additives, poly(m-xylene adipamide) (MXD6), and/or anthranilamide (2-aminobenzamide) as potential aldehydes scavengers were carried out. Mostly VOCs observed in the PET bottles analysed were identified in a neat ESBO sample. The presence of the ESBO additive in the PET-bottle fragments was also observed by matrix-assisted laser desorption/ionization time of flight mass spectrometry analysis (MALDI?TOF MS). The ESBO sub-products were not observed in the virgin btlg-PET pellets analysed by both HS-GCρMS and MALDI?TOF MS. These results suggest that the VOCs come from an ESBO additive probably loaded during the blow-moulding processes used for the manufacturing of PET bottles. Further studies established that MXD6 (1%w), an efficient oxygen scavenger, could be also used as AA scavenger even in the presence of the commonly used anthranilamide.

7) Impact of nanoparticles on the environmental sustainability of polymer nanocomposites based on bioplastics or recycled plastics - A review of life-cycle assessment studies
S.Carroccio, P.Scarfato, E.Bruno, P.Aprea, N.TzDintcheva, G.Filippone
Journal of Cleaner Production  335,  130322  - 2022
Adding nanoparticles to a host polymer can lead to performance improvements that can be twice as beneficial to the environment: first, sustainable nanocomposites based on bioplastics or recycled plastics could replace ubiquitous petroleum-based polymers; second, substantial plastic saving could be achieved by profiting from the superior specific properties of the nanocomposites. Nevertheless, the inherent environmental burden of nanoparticles can compromise the expected benefits. Here we address the controversial issue of the environmental sustainability of "green" polymer nanocomposites based on bioplastics and recycled plastics. A critical review of life-cycle assessment studies regarding nanocomposites and their individual constituents is presented. Nanoparticles have a remarkable environmental impact despite their typically low content. Except for organo-clays and graphene, the production of common nanofillers (nanocellulose, titanium dioxide, silver and, above all, carbon nanotubes) emits relevant amounts of greenhouse gases and requires high energy, nullifying the advantages of using green polymer matrices. Reaching high performance becomes hence crucial to make polymer nanocomposites truly sustainable through material saving. For this purpose, increasing the content of nanoparticles or functionalizing them to enhance their dispersion in the host polymer can unexpectedly entail environmental benefits.

IPCB graphical abstract

8) Additive Manufacturing Processing of Plastics for Mass Production of Composites Tooling: Technical and Economic Analysis
G.Cicala, C.Tosto, G.Recca, A.Patti
Macromolecular Symposia  395(1),  2000256  - 2021
The present paper focuses on the use of several additive manufacturing (AM) techniques for tooling manufacturing for composite parts production. A geometry that prevents mandrel removal is selected and it is analyzed in a real industrial environment for composites production using autoclave molding. The use of two different AM mandrels is evaluated: fused deposition modeling and liquid crystal display. The results are analyzed in terms of composites part quality, processing time and final part cost.

9) Kinetic Study of the Thermal Dehydration of Fly Ash Filled Geopolymers
I.Blanco, G.Cicala, C.Tosto, G.Recca, G.Dal Poggetto, M.Catauro
Macromolecular Symposia  395(1),  2000225  - 2021
Metakaolin-based geopolymers at different percentage of fly ash (namely 25, 50, and 70% wt) are prepared by using recycled fly ash, aiming at reducing the amount of waste to be treated or disposed in landfills. The synthesized samples are subjected to the thermogravimetric analysis (TGA) to investigate the kinetics of dehydration process. To this purpose, TGA data are treated by the Kissinger method to calculate the apparent activation energy (Ea) of dehydration. The obtained kinetics parameters are discussed and compared with each other and with those obtained for the control geopolymer. A decrease in Ea values of the filled geopolymers is found, showing the effect of the fly ash in reducing the dehydration rate. A classification among the samples at different percentage of fly ash is also drawn up, showing the reaching of a plateau at percentage above the 50 wt%.

10) Extraction and characterisation of bioactive proteins from Pongamia pinnata and their conversion into bioproducts for food packaging applications
D.Nataraj, V.Guna, P.Battampara, N.G.Shivashankara, P.Rizzarelli, N.Reddy
Journal of Bioactive and Compatible Polymers   - 2021
In this research, proteins were obtained from Pongamia pinnata oil meal and subsequently converted into films and compression molded into various packaging products. Films with a maximum tensile strength of 1.9 MPa were obtained when 15% citric acid was used as the crosslinker. Minimum swelling of 120% was seen in 20% citric acid crosslinked film whereas the uncrosslinked films readily disintegrated in water. The protein films had excellent antioxidant properties with an IC50 value of 14.6 μg/ml compared to 26.9 μg/ml for the standard ascorbic acid. The pongamia protein-based bioproducts showed good activity against Bacillus cereus and Aspergillus niger. Unique properties, low cost, and large availability make pongamia proteins an ideal biopolymer for the development of green and sustainable materials and bioproducts.

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