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STAFF italian version

Dr. Domenico Garozzo

Dr. Garozzo Domenico

EDUCATION AND TRAINING

1988Ph. D. in Chemical Sciences, University of Catania;
1981 "Laurea" in Chemistry, University of Catania.

EMPLOYMENT AND RESEARCH EXPERIENCE

2019 to present Head of Institute for Polymers, Composites and Biomaterials (IPCB CNR) of Catania;
2014 to present Senior Research Scientist, CNR, Institute for Polymers, Composites and Biomaterials (IPCB);
1993 to present Head of the Biopolymers Research Group, CNR, ICTP and IPCB;
1991 to present Member of the Scientific Steering Committee, CNR, ICTP and IPCB;
2004 to 2012 Adjunct Professor University of Catania;
2001 to 2004 Senior Scientist, CNR, Institute of Chemistry and Technology of Polymeric Materials (ICTP);
1988 to 2000 Research Scientist, CNR, ICTP;
1982 to 1988 Research Associate in the Polymer Laboratory, Chemistry Dept., University of Catania.

PROFESSIONAL EXPERIENCE AND RESEARCH INTERESTS

Dr. Garozzo's research centers on the characterization of natural and synthetic macromolecules. He developed Mass Spectrometry as analytical and structural tools for the analysis of polymers by the introduction of the SEC-MALDI technique, that is now universally used for the mass spectrometric analysis of polysaccharides and synthetic polymers. Afterwards, his studies explained why it is not possible to analyze polydisperse macromolecules, such as polysaccharides and most of the synthetic polymers, by MALDI MS without a pre-fractionation. In the field of natural macromolecules, his researches disclosed a sample preparation procedure able to obtain high quality MALDI mass spectra of R-type lipopolysaccharides. In this way, structural elucidations by MALDI MS of many LPS were obtained (Burkholderia dolosa, Pandoraea pulmonicola, Yersinia Pestis, Loktanella rosea, B. cenocepacia, vietnamiensis, multivorans, and many others).
His most recent field of research is human serum glycomics. His research in this field led to the discovery of three new genetic diseases due to Congenital Glycosylation Defects (CDG) (MAN1-B1 Deficiency, SLC35A3 mutation and DPM2-CDG) as well as the understanding of the bio-molecular basis of these diseases. He also contributed to a better understanding of Galactosemia.
More recently, he found that N-glycan alterations in CSF leads to very early detection of Alzheimer Disease (prior to the Mild Cognitive Impairment status) and new pharmaceutical targets.

Dr. Domenico Garozzo is author/co-author of more than 140 scientific publications in international journals with more than 4500 citations and h index = 37 (Google Scholar)

Awards and Honors

2016Berti Medal from Italian Chemical Society (SCI), Carbohydrate Chemistry group for his Research in Carbohydrate Chemistry.

Recipient of Research Grants

2018 to 2018Research Grant Mizutani Foundation for Glycoscience ;
2011 to 2015FIRB MERIT (MEdical Research In Italy) (final report);
2010 to 2012PRIN 2009 (final report);
2009 to 2010CNR/CONICET Joint project;
2007 to 2010PRIN 2007 (final report);
2005 to 2009FP6 Coordination Action: "EUROGLYCANET LSHM-2005-512131" (final report);
2005 to 2008APQ Regione Siciliana - MIUR project RS-20;
2002 to 2005Legge 449/97 progetto "PROFSICURI";
1994 to 1999EEC Structural Funds (Objective 1 P. O. MURST CNR).

Research agreement with private contractors

2003 to 2006Research grants SIFI Spa;
2005 to 2005Research grants Eurand Spa;
2002 to 2002Research grants Indena Spa;
2001 to 2001Research grants SIFI Spa;
2000 to 2001Research grants Indena Spa;
1998 to 1999Research grants with Pharmacia & Upjohn.

Reviewer for the following grant agencies

2019 NWO Neatherlands Organisation for Scientific Research;
2016 UEFISCDI Romanian Executive Agency for Higher Education, Research,
Development and Innovation Funding;
2016 ANVUR (MIUR Ministry of Education and Research);
2011 to 2012 OTKA Hungarian Scientific Research Fund;
2009 to 2009 HRB Health Research Board (Ireland).

Editorial Board

2012 to present associate editor of the Journal of Integrated-OMICS. A methodological Journal;
2008 to presentmember of Open Glycoscience Journal editorial board;
2008 to presentmember of Open Proteomics Journal editorial board;
2007 to 2017member of Journal of Proteomics (Elsevier) editorial board;
2010 Jan to 2010 Jun member of Nature reader panel.

Conference Chair

Dr. Domenico Garozzo chaired the following international workshop on mass spectrometry of polymers and biopolymers in Catania:
2007II Italian Proteomic Association Conference Acitrezza (Catania), Italy (June 2007);
2003MALDI and ESI MS after the 2002 Chemistry Nobel Prize
(February 2003 -Catania, Italy);
1999Mass Spectrometry of Polymers (December 1999 -Catania, Italy);
1997Application of MALDI-TOF MS in the Characterization of Synthetic and Biological
Polymers (October 1997 -Catania, Italy).

National Committees

2009 to 2014 Board Member of Carbohidrate Chemistry group (Italian Chemical Society);
2006 to 2011 Board Member of Italian Proteomic Association (ItPA);
2004 to 2006 Board Member of Italian HUPO.

Education and teaching Activities

2016 to 2017 University of Catania -Advanced Methods in Macromolecular chemistry (21 lectures);
2008 to 2009 University of Catania -Biopolymers (12 lectures);
2007 to 2008 University of Catania -Biopolymers (12 lectures);
2006 to 2007 University of Catania -Biopolymers (12 lectures);
2005 to 2006 University of Catania -Biopolymers (12 lectures);
2004 to 2005 University of Catania -Polymer Chemistry and lab (2 lectures).

Membership

Italian Chemical Society (SCI);
American Mass Spectrometry Society (ASMS);
Society for Glycobiology;
American Society for Biochemistry and Molecular Biology (ASBMB).

BOOK CHAPTERS

A.Palmigiano, A.Messina, L.Sturiale, D.Garozzo
Advanced LC-MS Methods for N-Glycan Characterization
Comprehensive Analytical Chemistry. Chapter 6 (ISSN 0166-526X) 79, 147-172 (2018)

P.L.Calvo, M.Spada, I.Rabbone, M.Pino, F.Porta, F.Cisarò, S.Reggiani, A.B.Cefalù, L.Sturiale, D.Garozzo, D.J.Lefeber, J.Jaeken
An Unexplained Congenital Disorder of Glycosylation-II in a Child with Neurohepatic Involvement, Hypercholesterolemia and Hypoceruloplasminemia
JIMD Reports 35, 1-7 (2017)

R.Zeevaert,F.De Zegher, L.Sturiale, D.Garozzo, M.Smet, M.Moens, G.Matthijs, J. Jaeken
Bone Dysplasia as a Key Feature in Three Patients with a Novel Congenital Disorder of Glycosylation (CDG) Type II Due to a Deep Intronic Splice Mutation in TMEM165
JIMD Reports 8, 145-152 (2013)

A.Palmigiano, D.Garozzo
From micro- to femto-moles, from small to giant molecules: the route of modern Mass Sectrometry
Seminars in organic synthesis 264-279 (2011) ISBN 978-88-86208-68-0

M.B.Bistuè Millòn, M.A.Delgado, N.B.Azar, N.Guelbert, L.Sturiale, D.Garozzo, G.Matthijs, J.Jaeken, R.Dodelson de Kremer, C.G.Asteggiano
Two Argentinean Siblings with CDG-Ix: A Novel Type of Congenital Disorder of Glycosylation?
JIMD Reports 1/2011, 65-72 (2011)

C.W.Fung. G.Matthijs, L.Sturiale, D.Garozzo, K.Y.Wong, R.Wong, V.Wong, J.Jaeken
COG5-CDG with a Mild Neurohepatic Presentation
JIMD Reports DOI 10.1007/8904_2011_61, (2011)

D.Garozzo, E.Spina, R.Cozzolino
Spettrometria di Massa MALDI TOF di Macromolecole
AIM Magazine 54(1), 33 (2000)

D.Garozzo
Maldi Ms of oligo and polysaccharides in Mass Spectrometry in the Biomolecular Sciences, R. M. Caprioli et al
Kluwer Academic Publishers 1997, 477 (1997)

PLENARY, KEYNOTE LECTURES AND INVITED SEMINARS

Neural N-glycans in Alzheimer’s and other diseases
1st International Conference on the Glycobiology of Nervous System. From the Genome Research Era to the Glycome September 2nd - 5th , 2017, Korea University, Seoul, Korea (2017)

N-glycosylation of Chloroviruses: the end of a paradigm
11th Jenner glycobiology and medicine Symposium, National Centre for Scientific Research (CNRS), Paris, France, 19-21 April 2015 , (2015)

Cerebrospinal Fluid N-Glycomics May Enable Early Diagnosis in Alzheimer Disease
XIV Convegno-Scuola sulla Chimica dei Carboidrati, Pontignano (Si), 22-25 Giugno 2014 , (2014)

CSF N-GLYCANS PROFILES TO INVESTIGATE BIOMARKERS IN ALZHEIMER'S DISEASE
17th European Carbohydrate Symposium (July 7 -11 2013 Tel-Aviv, Israel) , (2013)

Structure of very unusual N-Glycans Associated with the Major Capsid Protein of Chlorovirus PBCV-1: Nature can synthesize a different class of complex N-Glycans
International symphosium on chemical glycobiology (June 29-July 1 2013 Shanghai, China) , (2013)

Maldi mass spectrometry for the structural investigation of intact lipopolysaccharides
Atti XIII Convegno-Scuola sulla Chimica dei Carboidrati 24-27 giugno 2012 Certosa di Pontignano (Siena) , PC-19 (2012)

Identification of N-Glycosylation in the CSF in Patients with Alzheimer’s disease by MALDI Mass Spectrometry
Massa 2012 Congresso della Divisione di Spettrometria di Massa della Società Chimica Italiana (SCI) 1-5 Luglio 2012, Mondello (PA) , (2012)

Clinical and biochemical characterization of a CDG-I patient with fetal akinesia
4th International Meeting on Congenital Disorders of Glycosylation (Leuven, Belgium, 13-14 January 2011) , 49 (2011)

The MALDI TOF/TOF Mass Spectrometer as a Chemical Lab for the structural characterization of lipooligosaccharides
16th European Carbohydrate Symposium (July 3-7, Sorrento -Naples, Italy) , 45 (2011)

From micro- to femto-moles, from small to giant molecules: the route of modern Mass Sectrometry
Seminars in organic synthesis SCI June 13-17, 2011 Gargnano (BS), 264-279 (2011)

Quantitative proteomic analysis of human tear fluids using differentially labelled tags iTRAQ with LC-MALDI MS and MS/MS in VKC Patients
Quantitative Techniques in Mass Spectometry-Based Proteomics 12th 13th October 2009 Vienna: IMP/IMBA , (2009)

LC MALDI MS nell'analisi del fluido lacrimale
Cromatografia Nano Capillare e Spettrometria di Massa Applicazioni di Proteomica - Pisa 22 Aprile 2009 (Area della Ricerca del CNR) , (2009)

Multiplexed glycoproteomic analysis of glycosylation disorders by sequential IgY immunoseparation and MALDI TOF MS
XI Convegno-Scuola sulla Chimica dei Carboidrati, Pontignano (Si), 22-26 Giugno 2008 , (2008)

Multiplexed glycoproteomic analysis of glycosylation disorders by sequential IgY immunoseparation and MALDI TOF MS
XXI Congresso Nazionale di Chimica Analitica, Arcavacata di Rende (CS), 21 - 25 Settembre 2008 , (2008)

Multiplexed glycoproteomic analysis of glycosylation disorders by sequential IgY immunoseparation and MALDI TOF MS
3rd International Meeting on Congenital Disorders of Glycosylation. 18-19 October, 2007, Paris, France (2007)

Glycoproteomics of congenital disorders of glycosylation and secondary glycosylation disorders
Italian Proteomic Association. 2nd Annual National Conference, 26-29 Giugno 2007, Acitrezza (CT), Italy (2007)

Exopolysaccharides as Bacterial Defence Tools: the Case of Burkholderia cepacia complex
14th European Carbohydrate Symposium (EUROCARB 2007), Lubeck (Germania), 2-7 Settembre, 2007 (2007)

Structural Analysis of the Polysaccharides from Echinacea angustifolia Radix " XVIII Convegno Italiano di Scienza e Tecnologia delle Macromolecole, Catania, 16-20 Settembre, 2007 (2007)

Dall'analisi dei monosaccaridi all'analisi del glicoma; dalle micromoli alle femtomoli: i progressi della spettrometria di massa nell'analisi dei carboidrati
X Convegno-scuola sulla chimica dei carboidrati, 25-29 Giugno 2006, Certosa di Pontignano - Siena (2006)

Analisi del glicoma del fluido lacrimale in pazienti affetti da disordini congeniti della glicosilazione (CDG)
X Convegno-scuola sulla chimica dei carboidrati. 25-29 Giugno 2006. Certosa di Pontignano - Siena (2006)

Advances in purification methods of serum glycoproteins for MALDI_MS analysis of N-Glycome in patients with glycosylation disorders.
2005 Annual Meeting of the Society for Glycobiology. 9-12 November, 2005. Boston (2005)

Mass spectrometric approaches for the N-glycosylation analysis in congenital disordrs of glycosylation (CDG) and galactosemia
Italian Human Proteomic Organization (IHUPO). Terzo Congresso Nazionale. 29-Settembre- 1 Ottobre 2005, Lodi-Milano (2005)

Hypoglycosylation with increate fucosylation and branching of serum transferrin N-glycans in untreated galactosemia
1st Euroglycanet meeting, March, 28-30, 2005, Athens, Greece (2005)

Identificazione rapida di batteri mediante spettrometria di massa MALDI-TOF: dallo spettro del lipooligosaccaride all’individuazione di batteri gram-negativi
Convegno finale del progetto Trattamento di prodotti freschi altamente deperibili per garantirne qualità e sicurezza e salubrità 16-19 Marzo, 2005, Ariano Irpino (AV) (2005)

Mass spectrometric strategies for the N-glycosylation analysis of serum glycoproteins in patients with congenital disorders of glycosylation (CDG) and galactosemia
GLYCO XVIII. XVIII International Symposium on Glycoconjugates, September 4-9, 2005, Firenze, Italy (2005)

Proteomic Analysis of Human Tear Fluids in Healthy and Pathological Conditions
53rd ASMS Conference (June 5-9 2005) , (2005)

Increased fucosylation and branching of serum transferrin N-glycans in long-term untreated galactosemic patients
US/Japan Glyco 2004 - Joint meeting of the society for glycobiology and the japanese society of carbohydrate research. November 17-20, 2004, Honolulu, Hawaii (2004)

Glycomics: a frontier in proteomics
Primiero discussion group on mass spectrometry. New frontiers in proteomics . November 7-10, 2004. Fiera di Primiero (TN) (2004)

New Fragmentation Mechanisms in MALDI-TOF/TOF MS/MS of Carbohydrates
International Symposium on Mass Spectrometry in Proteomics and Molecular Profiles. 29th January 2004. Università della Calabria (2004)

Caratterizzazione strutturale di polisaccaridi mediante spettrometria di massa
XXVI Convegno Scuola dell'Associazione Italiana di Scienza e Tecnologia delle Macromolecole, Gargnano (BS) 24-28 Maggio, 2004 , (2004)

Analisi del Glicoma del Siero di Pazienti Affetti da Disordini Congeniti della Glicosilazione (CDG) e da Galattosemia
IX Convegno sulla Chimica dei Carboidrati, Certosa di Pontignano (Siena), 21-23 Giugno, 2004 (2004)

Glycomics of human serum: mass spectrometry investigations of serum glycoproteins in patients with congenital disorders of glycosylation (CDG) and glactosemia
2nd Italian Human Proteome Organization National Meeting. Proteomics impact in basic and clinical research. 16-18 September, 2004 - Chieti, Italy (2004)

Preliminary results on proteomics of human tear fluids : Lack of bioactive peptides and defensins in disease subjects
2nd Italian Human Proteome Organization National Meeting. Proteomics impact in basic and clinical research. 16-18 September, 2004 - Chieti, Italy (2004)

Determination of linkage positions and sequence of complex carbohydrates by MALDI TOF-TOF mass spectrometry.
Primo congresso Nazionale IHUPO, 26-27 Settembre 2003. Napoli, Italy (2003)

Analysis of human tear proteins by capillary LC/ESI-MS
Primo congresso Nazionale IHUPO, 26-27 Settembre 2003. Napoli, Italy (2003)

Structural characterization of the O-specific lipopolisaccharide chains by MALDI-MS
12th European Carbohydrate Symposium, July 6-11, 2003, Grenoble, France (2003)

Identification of some adulteration in milk and in water buffalo mozzarella cheese by MALDI TOF MS
Abstracts of the 51st Conference on Mass Spectrometry and Allied Topics, Montreal, June 2003, 1704 (2003)

New Results on MALDI MS of Widely Polydisperse Hydrosoluble Polymers
50th ASMS Conference on Mass Spectrometry and Allied Topics, Orlando, Florida, June 2-6, 2002, (2002)

Structure analysis of underivatized oligosaccharides using postsource decay with collision-induced fragmentation, in matrix-assisted laser desorption ionization mass spectrometry
47th ASMS Conference on Mass Spectrometry and Allied Topics, Dallas, Texas, June 13-17, 1999, (1999)

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